Order zoloft online
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The mechanism of action of sertraline is presumed to be linked to its ability to inhibit the neuronal reuptake of serotonin. It has only very weak effects on norepinephrine and dopamine neuronal reuptake. At clinical doses, sertraline blocks the uptake of serotonin into human platelets.
Like most clinically effective antidepressants, sertraline downregulates brain norepinephrine and serotonin receptors in animals. In receptor binding studies, sertraline has no significant affinity for adrenergic (alpha 1, alpha 2 and beta), cholinergic, GABA, dopaminergic, histaminergic, serotonergic (5-HT1A, 5-HT1B, 5-HT2) or benzodiazepine binding sites.
In placebo-controlled studies in normal volunteers, sertraline did not cause sedation and did not interfere with psychomotor performance.
Pharmacokinetics: Following multiple oral once-daily doses of 200 mg, the mean peak plasma concentration (C max) of sertraline is 0.19 µg/mL occurring between 6 to 8 hours post-dose. The area under the plasma concentration time curve is 2.8 mg h/L. For desmethylsertraline, C max is 0.14 µg/mL, the half-life 65 hours and the area under the curve 2.3 mg h/L. Following single or multiple oral once-daily doses of 50 to 400 mg/day the average terminal elimination half-life is approximately 26 hours. Linear dose proportionality has been demonstrated over the clinical dose range of 50 to 200 mg/day.
Order Zoloft 25 mg: Each yellow capsule contains: sertraline HCl equivalent to 25 mg of sertraline. Nonmedicinal ingredients: cornstarch, lactose (anhydrous), magnesium stearate and sodium lauryl sulfate. Capsule shell: D&C Yellow No. 10, FD&C Yellow No. 6, gelatin and titanium dioxide. Tartrazine-free. White high density polyethylene bottles of 100.
Order Zoloft 50 mg: Each white and yellow capsule contains: sertraline HCl equivalent to 50 mg of sertraline. Nonmedicinal ingredients: cornstarch, lactose (anhydrous), magnesium stearate and sodium lauryl sulfate. Capsule shell: D&C Yellow No. 10, FD&C Yellow No. 6, gelatin and titanium dioxide. Tartrazine-free. White high density polyethylene bottles of 100 and 250.
Order Zoloft 100 mg: Each orange capsule contains: sertraline HCl equivalent to 100 mg of sertraline. Nonmedicinal ingredients: cornstarch, lactose (anhydrous), magnesium stearate and sodium lauryl sulfate. Capsule shell: D&C Yellow No. 10, FD&C Red No. 40, gelatin and titanium dioxide. Tartrazine-free. White high density polyethylene bottles of 100.