al-PRAY-zoe-lam
Buy Cheap Xanax
Alprazolam
Pronouncation: (al-PRAY-zoe-lam)
Class: Antianxiety, Benzodiazepine
Trade Names:
Alprazolam Intensol
- Oral solution 1 mg/mL
Trade Names:
Xanax
- Tablets 0.25 mg
- Tablets 0.5 mg
- Tablets 1 mg
- Tablets 2 mg
Buy Cheap Xanax
Trade Names:
Xanax XR
- Tablets, extended-release 0.5 mg
- Tablets, extended-release 1 mg
- Tablets, extended-release 2 mg
- Tablets, extended-release 3 mg
Trade Names:
Niravam
- Orally disintegrating tablets 0.25 mg
- Orally disintegrating tablets 0.5 mg
- Orally disintegrating tablets 1 mg
- Orally disintegrating tablets 2 mg
Apo-Alpraz (Canada)
Apo-Alpraz TS (Canada)
Gen-Alprazolam (Canada)
Novo-Alprazol (Canada)
Nu-Alpraz (Canada)
ratio-Alprazolam (Canada)
Xanax TS (Canada)
Pharmacology
Buy Cheap Xanax
Potentiates action of GABA, an inhibitory neurotransmitter, resulting in increased neuronal inhibition and CNS depression, especially in limbic system and reticular formation.
Pharmacokinetics
Absorption
Readily absorbed; T max is 1 to 2 h; C max is 8 to 37 ng/mL (0.5 to 3 mg doses).
Distribution
80% protein bound. Crosses the placenta and is excreted in breast milk.
Metabolism
Metabolized in the liver to alpha-hydroxy-alprazolam (activity is approximately 50% that of alprazolam) and a benzophenone derivative (inactive).
Elimination
The t ½ is approximately 16.3 h. Excreted in the urine.
Special Populations
Hepatic Function Impairment
The t ½ is approximately 19.7 h in those with alcoholic liver disease.
Elderly
The t ½ is approximately 16.3 h.
Obese
The t ½ is approximately 21.8 h.
Indications and Usage
Treatment of panic disorders with or without agoraphobia ( Niravam , Xanax , Xanax XR ); management of anxiety disorders or for short-term relief of symptoms of anxiety, including anxiety associated with depression ( Niravam , immediate-release tablets and oral solution).
Unlabeled Uses
Treatment of irritable bowel syndrome, depression, PMS.
Contraindications
Hypersensitivity to other benzodiazepines; acute narrow-angle glaucoma; patients receiving itraconazole or ketoconazole.
Dosage and Administration
Panic Disorder
Initial dose
Buy Cheap Xanax
PO Immediate-release tablets: 0.5 mg 3 times daily; if needed, increase by max 1 mg/day every 3 to 4 day. May require more than 4 mg/day. Extended-release tablets: start with 0.5 to 1 mg daily (suggested daily dose ranges between 3 and 6 mg).
Anxiety Disorder (Immediate-Release Tablets and Oral Solution)
Adults
PO Immediate-release tablets and oral solution: 0.25 to 0.5 mg 3 times daily (max, 4mg/day in divided doses). Extended-release tablets: Start with 0.5 mg daily and gradually increase if needed (suggested total daily dose range 3 to 6 mg/day).
Elderly/Debilitated Patients
Adults
PO Immediate-release tablets: 0.25 mg 2 to 3 times daily; may increase dose gradually. Extended-release tablets: 0.25 mg 2 to 3 times daily. May increase dose gradually.
Xanax should be used with caution in elderly or weak patients, and in those with lung disease, alcoholic liver disease, or any disorder that could hinder the elimination of the drug.
Possible food and drug interactions when taking Xanax
Xanax may intensify the effect of alcohol. Do not drink alcohol while taking this medication.
Never combine Xanax with Sporanox or Nizoral. These drugs cause a buildup of Xanax in the body.
Buy Cheap Xanax
If Xanax is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is important to check with your doctor before combining Xanax with the following:
Amiodarone (Cordarone)
Antihistamines such as Benadryl and Tavist
Carbamazepine (Tegretol)
Certain antibiotics such as Biaxin and erythromycin
Certain antidepressant drugs, including Elavil, Norpramin, and Tofranil
Cimetidine (Tagamet)
Cyclosporine (Neoral, Sandimmune)
Digoxin (Lanoxin)
Diltiazem (Cardizem)
Disulfiram (Antabuse)
Ergotamine
Fluoxetine (Prozac)
Fluvoxamine
Grapefruit juice
Isoniazid (Rifamate)
Major tranquilizers such as Mellaril and chlorpromazine
Nefazodone
Nicardipine (Cardene)
Nifedipine (Adalat, Procardia)
Oral contraceptives
Other central nervous system depressants such as Valium and Demerol
Paroxetine (Paxil)
Propoxyphene (Darvon)
Sertraline (Zoloft)
Special information if you are pregnant or breastfeeding
Do not take this medication if you are pregnant or planning to become pregnant. There is an increased risk of respiratory problems and muscular weakness in your baby. Infants may also experience withdrawal symptoms. Xanax may appear in breast milk and could affect a nursing infant. If this medication is essential to your health, your doctor may advise you to stop breastfeeding until your treatment with this medication is finished.
Recommended dosage
ADULTS
Anxiety disorder
The usual starting dose of Xanax is 0.25 to 0.5 milligram taken 3 times a day. The dose may be increased every 3 to 4 days to a maximum daily dose of 4 milligrams, divided into smaller doses.Tags:Buy Cheap Xanax